The most frequently mutated gene was TP53.[6,11] Importantly, co-occurrence of TP53 mutations and TP53 deletions resulting from chr17 abnormalities was detected in PEL patients, suggesting more than a single TP53 abnormality may represent a pathognomonic signal associated with PEL.[11] Conversely, mutations commonly found in other types of AML, such as FLT3, NPM1, and CEBPA, are very rare in PEL.[6] In this patient, TP53, GATA2, TET2 mutations, TP53 deletion were identified at initial diagnosis. The gene discussed is CEBPA; the disease is primary effusion lymphoma.