CXCL8 and Sepsis: Inflammation is one of the most important clinical manifestations of sepsis.[14–16] During inflammation, mononuclear macrophages secrete IL-8 from the blood in tissues.[17] The upregulation of IL-8 in vitro indicates the deterioration of the disease and the higher tendency to death.[18,19] In addition, it has been reported that IL-8 is associated with the progression of sepsis.[20,21] IL-8 blocking therapy is beneficial to the prognosis of septicemia by blocking systemic inflammatory response.