FOLH1 and bone metastasis: According to the analysis results, the (SEN) and SPE of 68Ga-PSMA-PET/CT in the diagnosis of bone metastasis were superior to that of bone scan, the +LR for 68Ga-PSMA-PET/CT and bone scan were 88.45 and 6.67, -LR were 0.05 and 0.19, DOR were 1468.33 and 36.23, AUC and 95% CI were 0.9973(1.0000–0.9927), and 0.8838 (0.9584–0.8092), respectively (Figs. 3 and 4).