In a single case study, 68Ga-PSMA was absorbed in the skeletal region of Paget disease patients who had been diagnosed by biopsy.[27] This case illustrates recent findings that PSMA may also be overexpressed in tissues other than the prostate cancer, such as myeloma and renal cancer.[28,29] Because the “Pitfalls” of 68Ga-PSMA-PET/CT in the diagnosis of bone metastasis of prostate cancer can not be avoided, it is necessary to integrate the PET/CT, bone scan, CT, MRI, PSA, clinical and imaging follow-up, and apply pathology for diagnosis if necessary. The gene discussed is FOLH1; the disease is Paget disease.