Other authors also questioned the conclusions drawn by Wright et al with respect to the association between high D-dimer levels and TEG in the setting of fibrinolysis shutdown in COVID-19 patients.[33] Additional studies on COVID-19 patients who are not on anticoagulation are needed to confirm these conclusions, and the results should be correlated, at the very least, with corresponding levels in tPA and PAI-1. This evidence concerns the gene SERPINE1 and COVID-19.