Scheper et al analysed the intrinsic anti‐tumour reactivity of the intra‐tumoural TCR repertoire of CD8+ T‐cells in ovarian and colorectal cancer (CRC) samples and showed that the capacity to recognise autologous tumour is limited to a small minority of intra‐tumoural CD8+ T‐cells [39]. This evidence concerns the gene CD8A and neoplasm.