Similarly, compared to the control mice, the mice implanted with the PRDM4-silenced HeLa and SiHa cells (105 cells) showed larger tumor volumes, with a 2.6–3.7-fold increase in tumor size and a 1.7–2.1-fold increase in tumor weight; these mice also had a shortened tumor-free survival (Fig. 2E, G, p < 0.05). This evidence concerns the gene PRDM4 and neoplasm.