PRDM4 and squamous cell intraepithelial neoplasia: In our clinical specimens, PRDM4 protein expression was detected in normal cervix (NC, N = 38), high-grade squamous intraepithelial lesions (HSILs, N = 30), and invasive cervical squamous cell carcinoma (SCC, N = 60) using immunohistochemistry (IHC, Fig. 1D).