In conclusion, our study is the first to demonstrate that PRDM4 inactivates the PI3K/AKT signaling pathway by binding to the PTEN promoter and transactivating PTEN, blocking the cell cycle process by upregulating p21 and p27 expression and downregulating Cyclin D1 and CDK4 expression, ultimately inhibiting the cell proliferation and tumor growth of cervical cancer cells. Here, PRDM4 is linked to cervical cancer.