CPA6 and epilepsy: Second, although we only studied children whose epilepsy onset was before age 2 years, the duration follow-up for children without epilepsy was relatively short (2–5 years), and so these children may yet develop epilepsy.48,49 For example, the pathogenic variant in the CPA6 gene identified in our control group (children without epilepsy through at least 2 years of age) can increase epilepsy susceptibility into late childhood;38,39,41 longer duration of follow-up could result in re-classification of this proband.