Among children with post-neonatal epilepsy, two pathogenic/likely pathogenic variants and two VUS were in candidate genes that may alter susceptibility to epilepsy (CACNA1H, CASK, RBFOX3, and RYR3),9,29–31 and three pathogenic/likely pathogenic variants were in established and candidate genes that are associated with epilepsy syndromes with incomplete penetrance and variable expressivity (KCNT1, MAGI2, and PRRT2).32–34 Three of the five children with IS had pathogenic/likely pathogenic variants. The gene discussed is RYR3; the disease is epilepsy.