PPAT and Alzheimer disease: Since our Atase knockout mice exhibit activation of reticulophagy (Atase1−/− only) and macroautophagy (both Atase1−/− and Atase2−/−), we crossed our Atase knockout mice with the APPswe/PS1dE9 (henceforth referred to as APP/PS1) AD-like model to generate APP/PS1;Atase1−/− and APP/PS1;Atase2−/− mice.