After USP24 knockdown, the levels of P-gp, ABCG2, and ezrin were decreased, which indicated that USP24 as a deubiquitinating enzyme may stabilize P-gp, ABCG2, and ezrin to enhance the ability of pumping out of a drug from cancer cells (Fig. 2A, B and Supplementary Figs. 2C, D and 3C, E). This evidence concerns the gene EZR and cancer.