We found significantly higher levels of activin A in the plasma of high tumor-burden KPC mice (2.514 ng/ml ± 0.4252, n = 4) compared to wild type (0.1363 ng/ml ± 0.03309, n = 12), KC (0.2170 ng/ml ± 0.08171, n = 6) and low burden KPC mice (0.0965 ng/ml ± 0.01900, n = 4) (Fig. 3B). Here, CALCA is linked to neoplasm.