Moreover, lovastatin treatment in combination with troglitazone exhibited antiproliferation effects in a mouse xenografted anaplastic thyroid cancer model, which might be due to the effects of cell cycle arrest at the G0/G1 phases and reduction in hyperphosphorylated retinoblastoma protein-E2F1 signaling18. The gene discussed is E2F1; the disease is thyroid gland undifferentiated (anaplastic) carcinoma.