CD8A and colorectal carcinoma: In the NICHE trial, the PDO-immune cell co-culture drug screen results (based on the IFN-ƴ production by CD-8+ T-cells) matched the clinical response to neoadjuvant nivolumab and ipilimumab in six CRC patients, all non-responders with proficient mismatch repair (pMMR) tumours22.