Patients with diabetes had a more pronounced decrease in FGF21 levels after dexamethasone, as compared to patients without diabetes (− 233 pg/mL [95%CI − 322 to − 144 pg/mL] vs. − 80 pg/mL [95%CI − 143 to − 18 pg/mL]; p < 0.001) (Fig. 3). The gene discussed is FGF21; the disease is diabetes mellitus.