Moreover, a significantly increased risk of overall mortality (HR 1.10; 95% CI 1.01–1.27; p = 0.039) and cardiovascular (HR = 1.13; 95% CI 1.01–1.34; p = 0.036) was found even after multiple adjustments for age, gender, weight, height, history of arterial hypertension, dyslipidemia, diabetes, smoking, heamoglobin, hematocrit, C-reactive protein, atrial fibrillation, microalbuminuria, GFR, LV-EF and number of exercise training sessions attended. The gene discussed is CRP; the disease is diabetes mellitus.