In this study, the predictability of the NUDT15 variant allele for leukopenia was 36%, which is lower than the value of 42.3% reported by Xiaoli Fan et al.19 Schaeffeler et al. observed that the NUDT15 variant contributed to 13% of AZA-induced leukopenia among Caucasian people; further, they observed that in combination, TPMT and NUDT15 variants explain ~ 50% of myelosuppression among AZA users of European descent35. This evidence concerns the gene TPMT and Decreased total leukocyte count.