In fact, exogenous administration of human derived-AGP (hAGP) to unilateral ureteral obstruction-induced renal fibrotic mice and to adriamycin-induced nephropathy mice suppressed renal fibrosis and proteinuria by changing macrophages polarization into M2-like anti-inflammatory macrophages in the kidney25,26. The gene discussed is ATP5MK; the disease is renal fibrosis.