An important number of cytokine levels were below the detection limit of the method (LOD and/or LLOQ) such as IL-2, IL-10, IL-11, IL-12 (p40), IL-12 (p70), IL-19, IL-27 (p28), IL-28A/IFN-λ2, IL-29/IFN-λ1, IFN-α2 and osteocalcin in both tumor and normal tissue control samples. This evidence concerns the gene IL27 and neoplasm.