The log-transformed levels which do not exhibit a normal distribution but exhibit statistically significant tumor vs. control differences via Wilcoxon tests were (in alphabetical order): CEA, Chitinase 3-like 1 (CHI3L1), IFN-γ, IL-8, IL-22, IL-35, LIGHT/TNFSF14, OCLN, MMP-1, MMP-3, sIL-6Rα, STAT1, STAT3, sTNFR1 and sTNFR2 (Fig. 2). This evidence concerns the gene MMP3 and neoplasm.