Also, we note the strongest five negative correlations (less than − 0.650): APRIL–MMP2 (concentration ratios in log scale) = − 0.761 (Pearson), APRIL-BAFF (concentrations in log scale) = − 0.740** (Pearson), APRIL-IL8 (concentrations ratios in log scale) = − 0.696** (Pearson), MMP3-LIGHT/TNFSF14 (concentrations in tumor) = − 0.684** (Spearman) and APRIL-sTNFR1 (concentrations in tumor) = − 0.667** (Spearman). This evidence concerns the gene TNFSF13B and neoplasm.