We report the existence of a panel of underexpressed markers [namely IL-2, IL-10, IL-11, IL-12 (p40), IL-12 (p70), IL-19, IL-27 (p28), IL-28A/IFN-λ2, IL-29/IFN-λ1, IFN-α2] in CRC patients, which should be further studied to reveal their role in establishing a pro-tumoral inflammatory conditions. The gene discussed is IFNL2; the disease is colorectal carcinoma.