STAT1 and cancer: Although there is tentative data suggesting that in some tumor cells both STAT1 and STAT3 post-transcriptional regulation are stimulated by ROS46, and specifically STAT3 phosphorylation can be activated47, there is insufficient data regarding colon cancer STAT1/3 ROS regulation, and this may be a good direction for further study as it could contribute to elucidate the role of ROS in CRC, and potentially clarify the controversial role of antioxidants in cancer treatment.