IRF3 and colorectal carcinoma: Moreover, in CRC it was demonstrated that β-catenin could inhibit the expression of IFN-β and interferon-stimulated gene 56 (ISG56) by interacting with the central transcription factor, interferon‐regulatory factor 3, blocking its nuclear translocation, responsible for the induction of IFN‐β and hence being essential for the activation of interferon responses33.