ECMO patients exhibit a range of coagulation abnormalities including: consumption of both procoagulant and anticoagulant factors10,11, thrombocytopenia, altered vWF multimers12, platelet dysfunction1, decreased anti-thrombin2, as well as increased D-dimer, prothrombin fragment 1.2 and thrombin-antithrombin complexes13. Here, F2 is linked to Thrombocytopenia.