To substantiate the observation that higher TXNIP level was associated with decreased proliferation in metastatic melanoma biopsies, we analyzed the profile of TXNIP expression in proliferating and resting A375 cells, as well as in C8161 cells, a cutaneous metastatic melanoma cell line that also harbor an activating mutation of BRAF commonly found in patient tumors17,19,20. Here, TXNIP is linked to metastatic melanoma.