Experimental and endogenous upregulation of integrin beta-3 expression indeed correlates with the malignant potential of human melanoma cells, with the transition from dysplastic nevi to invasive melanomas and with preferential metastatic seeding to the lung ; conversely, normal melanocytes or early-stage melanomas do not express integrin beta-324,25. The gene discussed is ITGB3; the disease is melanoma.