Among those actors of particular interest to melanoma metastasis, a strong increase in the expression of integrin beta-3 (ITGB3) and TIMP-2 was confirmed at the protein level in A375-shTXNIP versus A375-shScr human melanoma cells (Fig. 4F–G), while integrin alpha-11, collagen alpha3(VI), MMP-1 and MMP-14 proteins remained unaffected (Supp Fig. 3A–D). The gene discussed is MMP1; the disease is melanoma.