TXNIP and melanoma: Finally, downregulation of TXNIP expression levels by RGZ was not specific to the A375 metastatic cells, as it was also observed in the human melanoma cell lines WM35 (radial-growth phase), WM115 (vertical-growth phase), SK-MEL-28 (metastatic) and WM793 (metastatic) human melanoma cells (Fig. 1E).