Meanwhile, the CRISPR silencing of DRAP1 and CEBPZ in hundreds of cancer cell lines identifies them as common essential genes for proliferating cancer cell survival in general, whilst depletion of others such as ZKSCAN1 and ZNF146 reveal them as essential for certain cancer lineages (p < 0.0005, Supplementary Figure 6)48. Here, ZKSCAN1 is linked to cancer.