CD8A and infection: We observed in NYVAC-C Δ3-infected mice that, compared to IgG2b-treated mice, the inhibition of α4β1 integrin and infection with NYVAC-C Δ3 induced a significant increase of the magnitude of the HIV-specific CD8 T-cell responses (Fig. 6b, c), while the polyfunctionality was similar (Fig. 6d).