Conversely, the loss of B cells increased TGFβ+ microglia as well downregulated expression of Trem2, Clec7a, and Itgax in the hippocampus, i.e., replacement of DAM with microglia that eliminate Aβ oligomers and other neurotoxic debris8–10, reduced Aβ plaques and improved behavioral impairments of our AD mice. Here, TREM2 is linked to Alzheimer disease.