KLRK1 and lung cancer: In fact, we demonstrated that blocking of NKG2D attenuated γδ T-mediated cytolysis of DAC-pretreated H1299 lung cancer cells (Supplementary Fig. 8b), which suggests that conventional tumor recognition mechanisms by γδ T cells, such as NKG2D/NKG2DL interactions, partially contribute to γδ T killing of DAC-treated cells64.