To further elucidate the relationships between epigenetic proteins and immune synaptic cytoskeleton, we performed a gene network analysis of DAC transcriptomes in lung cancer cell lines by Ingenuity Pathway Analysis (IPA), which revealed an intimate interconnectedness between immune synaptic molecules, the cytoskeleton, and epigenetic proteins (Supplementary Fig. 12a). The gene discussed is PROS1; the disease is lung cancer.