PDK1 and neoplasm: Consistently, we found increased expression of HK2, PFKP, ENO4, PDK1 and LDHB, encoding key enzymes regulating glucose metabolism, in BMI1High;CHD7Low G4 MB tumour samples (Supplementary Fig. S3e) but not in G3 tumours with the same signature (Supplementary Fig. S3f), further confirming the relevance of the BMI1High;CHD7Low signature specifically for G4 MB subgroup.