CNP and neoplasm: Finally, in a somatic Nf1/Pten/p53 CRISPR-based mouse model, while the vast majority of tumour cells were SOX10+, a much greater proportion of tdTomato+ tumour cells differentiated to CC1+/CNP+/Ki67− immature oligodendrocyte cells in the white matter relative to the grey matter (Supplementary Fig. 3f–j).