While CRC patients with high levels of Rab7 had poorer OS (Fig. 6a), patients with high levels of both TRIM39 and Rab7 (TRIM39HighRab7High) had the poorest OS (Fig. 6b), suggesting that Rab7 and TRIM39 may be functionally synergized during CRC progression. Here, TRIM39 is linked to colorectal carcinoma.