Our findings with GST-Pull-down experiments show the presence of an IQGAP2-IQGAP1 complex in breast cancer cells, hinting at the possibility of masking the pro-oncogenic effects of IQGAP1 and subsequent reduction of the phospho-ERK levels in the cells, similar to the phenomenon observed in HCC21. The gene discussed is IQGAP1; the disease is breast carcinoma.