To understand how differences in KIR2D/HLA-C interactions potentially translated to functional outcomes, we initially compared NK cell recognition of three cell lines isolated from Burkitt lymphoma patients; Raji (HLA-C*03:04/C*04:01-C1/C2), Ramos (HLA-C*16:01-C1) and Namalwa (HLA-C*07:01/07:02-C1/C1). This evidence concerns the gene HLA-C and Burkitt lymphoma.