Among APOE4 males, we found association with AD for a large region of 1.9Mb on 3q12.1 comprising the genes CMSS1, COL8A1, FILIP1L, MIR548G, RPL24 and, in females, a 1.5Mb region on 2q33.2 comprising the ABI3 homologue ABI2, CARF, CYP20A1, FAM117B, FZD7, ICA1L, NBEAL1, RAPH1 and WDR12 genes. The gene discussed is APOE; the disease is Alzheimer disease.