We found however a large overlap among significant genes for the APOE3 and APOE4 strata (n=51) including BIN1, MS4A4A, MS4A6A, PICALM and SLC24A4 AD genes and a good number of ribosomal and electron transport mitochondrial proteins (ATP5I, ATP5O, ATP6V1E1, COX17, MRPL27, MRPL33, MRPL35, MRPS17, MRPS21, UQCRB). Here, PICALM is linked to Alzheimer disease.