In this analysis, the shortest list of APOE-specific genes was found in the APOE4 stratum, which showed the largest overlap with the APOE3 stratum; among the 45 significant genes shared by these strata, we identified several AD genes, including BIN1, MS4A4A, MS4A6A, PICALM and RIN3 in accordance with blood results. The gene discussed is BIN1; the disease is Alzheimer disease.