In blood 275, 284 and 278 genes passed the FDR threshold in the APOE2, APOE3 and APOE4 strata respectively with 15 common genes, associated with AD irrespective of the APOE haplotype, which include APOC1, CLPTM1, DNAJA1, ING3, LARP7, NGDN, RPA3, RPL36AL, RPS24, SOD1, SRP19, and four mitochondrial proteins (ATP5F1, ATP6V1D, MRPL51 and UQCRH). The gene discussed is RPA3; the disease is Alzheimer disease.