APOE and Alzheimer disease: We followed up genes with concordant profiles in both blood and cortex (upregulated or downregulated in AD cases vs controls) and showing opposite profiles in APOE2 and APOE4, which included 34 genes with overrepresentation of the gluconeogenesis and fructose metabolic pathways (FBP1, FBP2, SLC25A1) (Figure 5A).