METAP2 and Alzheimer disease: Overall, among these 38 RRA candidates, we identified a cluster of 11 overexpressed proteins in AD cases when compared to controls in the APOE3 stratum, but downregulated APOE4 AD cases including AIF1, APP, GDI2, HSP90AA1, METAP2, NACA, NCK1, PRDX1, RPS27A, SFTPD and UFC1 (Supplementary Figure 11); immunological functions associated to these proteins include leukocyte activation (APP, PRDX1, GDI2), Toll-like receptors (TLRs) cascade (APP, RPS27A, SFTPD) or phagocytosis (NCK1, HSP90AA1, SFTPD, AIF1) in line with our RRA findings.