Other therapeutic alternatives for weight loss and restoration of menstrual cyclicity such as multicomponent lifestyle intervention including diet, exercise and behavioral strategies [25], myo-inositol [26] and GLP-1 based therapies [27, 28] also need further exploration in overweight/obese patients with PCOS and high metabolic risk who are metformin non-adherent or metformin-intolerant. The gene discussed is GCG; the disease is polycystic ovary syndrome.