On the other hand, PND comorbid with anxiety showed a total of two DM CpGs in comparison with HC: at cg05385119 located just upstream of the ATP Binding Cassette Subfamily F Member 1 gene (ABCF1) (log twofold change − 0.21) and at cg00017362 (log twofold change 0.18) located upstream of Homo sapiens integrator complex subunit 10 gene (INTS10) (Table 3, Additional file 2: Fig. 2). The gene discussed is INTS10; the disease is Anxiety.