Nevertheless, we observed increased expression of salt-inducible kinase1 (SIK1) in the ipsilateral brain of HSD mice at 3 days after tMCAO (Supplementary Figure 1A-B), which was a direct effect of sodium stimulation [23] and revealed the salinized microenvironment in stroke lesion of HSD mice. The gene discussed is CHST3; the disease is stroke disorder.