Some studies have shown that enhanced PTTG3P expression stimulates the migration and invasion of ESCC cells, thus promoting the expression levels of PTTG1 and PTTG2 in vitro, and realizing its carcinogenic function by positively regulating its parent genes PTTG1 and PTTG2 [14]. Here, PTTG1 is linked to esophageal squamous cell carcinoma.