Yet, the mapped genes were highly relevant to PCa etiology and included known cancer drivers LDLRAD4, GMNN, COL1A1, CD38, PTPRN2, GTSE1 and CAMK2N1 in the risk signature and KLK2, AR, KLK3, SPDEF in the relapse signature. The gene discussed is KLK3; the disease is posterior cortical atrophy.