In the present study, our findings showed that kaempferol treatment caused the pharmacological inhibition of TGM2 in vitro and in vivo, and a negative correlation was observed between TGM2 expression and the regulation of ROS-dependent apoptosis, indicating that TGM2 may be a potential anticancer target of kaempferol for pancreatic cancer treatment. Here, TGM2 is linked to pancreatic neoplasm.