Compared to the ALS-nci group, patients in the ALS-ci group had significantly lower numbers of total T lymphocyte (996.50/μL vs 1247.00/μL, P = 0.005), CD4+ T lymphocyte (652.47/μL vs. 767.63/μL, P = 0.019), CD8+ T lymphocyte (262.00/μL vs. 360.00/μL, P = 0.019), and B lymphocyte (158.50/μL vs. 219.00/μL, P = 0.035). The gene discussed is CD4; the disease is amyotrophic lateral sclerosis.