CCL2 and type 2 diabetes mellitus: Type 2 diabetes is a risk factor of CAD, it was reported that miR-200 family members miR-200b, miR-200c, and miR-429 were upregulated in VSMC and aortas from type 2 diabetic db/db mice, and miR-200b, miR-429 mimics and target gene Zeb1 siRNAs increased the expression of inflammatory genes COX-2 and MCP-1 as well as monocyte binding to VSMC [45].