The circadian clock plays an important role in regulating diurnal changes in cardiac metabolism, heart rate, and blood pressure [28, 34], and there is evidence from both animal models [35, 36] and human studies [37–39] [40, 41] that disruption of the circadian clock adversely impacts the development of cardiovascular disease [27, 42, 43] and susceptibility to myocardial infarction [36, 44]. Here, CLOCK is linked to cardiovascular disorder.