Defined by the gradual buildup of plaqueon the artery walls, atherosclerosis has no symptoms in its mild formbut, dangerously, over time can lead to the onset of ischemic stroke17,18 and coronary artery disease.19 In atherosclerosis,HO-1 is induced during intraplaque hemorrhage (IPH), a rupture ofthe vulnerable plaque coating the artery walls. The gene discussed is HMOX1; the disease is atherosclerosis.