In ECs, decreased activity of the BMP9/10 signaling leads to over-activation of the pro-angiogenic factors VEGF-A and angiopoietin-2 (ANGPT-2), triggering EC hyperproliferation, as well as alterations in their permeability and migration, ultimately leading to vascular malformations [78, 83–85]. The gene discussed is ANGPT2; the disease is vascular malformation.