Importantly, the ability to both detect and treat some cancers has improved dramatically, such as for cancers of the breast72 and colorectum.73 Prostate-specific antigen screening remains controversial,74,75 but treatment for prostate cancer has become more effective.76 When esophageal cancer is detected early, evolving therapies have improved the cure rate.77 For pancreatic cancer, mortality rates have decreased little despite advances in imaging and surgery.78 The gene discussed is KLK3; the disease is esophageal cancer.