Importantly, the ability to both detect and treat some cancers has improved dramatically, such as for cancers of the breast72 and colorectum.73 Prostate-specific antigen screening remains controversial,74,75 but treatment for prostate cancer has become more effective.76 When esophageal cancer is detected early, evolving therapies have improved the cure rate.77 For pancreatic cancer, mortality rates have decreased little despite advances in imaging and surgery.78 This evidence concerns the gene KLK3 and Familial prostate cancer.