FFAR4 and lung carcinoma: In particular, GPR120 activation mediated by endogenousligands or the synthetic 4 increased tamoxifen resistance,which is dependent on ERK/Akt pathways, whereas GPR120 knockdown orantagonist 5 abrogated this effect.55 Although GPR120 is overexpressed in lung tissues, few studiesreported its involvement in lung cancer.