INS and type 2 diabetes mellitus: FFAswere able to enhance muscle and hepatic insulin sensitivity, increaseglucose infusion rate, promote hepatic lipid metabolism, and decreasehepatic steatosis in wild-type mice but not in GPR120 KO mice, highlightingits role in T2DM management.104 In humanislets, GPR120 expression is positively associated with insulin secretionand content but negatively with HbA1c percentage.