The presenceof LCFAs in foods highlighted their role in human nutrition, includinganti-inflammatory and cancer-preventive activities, with a particularemphasis on the gastrointestinal tract.46−50 Scientific evidence demonstrated that fat nutrientsare involved in cancer because FFAs targeted GPR120,51 showing a relationship with colorectal cancer, but alsowith melanoma, lung, prostate, and breast cancers.52 In breast tissues, GPR40 and GPR120 are both expressed.Their role was investigated in MCF-7 and MDA-MB-231 cell lines. This evidence concerns the gene FFAR4 and melanoma.