FFAswere able to enhance muscle and hepatic insulin sensitivity, increaseglucose infusion rate, promote hepatic lipid metabolism, and decreasehepatic steatosis in wild-type mice but not in GPR120 KO mice, highlightingits role in T2DM management.104 In humanislets, GPR120 expression is positively associated with insulin secretionand content but negatively with HbA1c percentage. This evidence concerns the gene INS and steatosis.