DPP4 and diabetes mellitus: Small study that included 25 DM patients treated with different DPP-4 inhibitors (19 on sitagliptin, 5 on vildagliptin and 1 on saxagliptin) reported significant improvement in LV longitudinal strain and E/e′, surrogates of LV systolic and diastolic functions, and important improvement in endothelial function, after 12 months of treatment despite no significant differences in weight, blood pressure, or lipid parameters [52].