Meta-analysis that compared parameters of LV systolic and diastolic function in DM patients treated with different antidiabetic drugs showed no difference in all parameters of LV diastolic function (e′, E/e′ and E/A) in patients treated with DPP-4 comparing with those who were treated with competitors (thiazolidinediones, SGLT-2 inhibitors and sulfonylurea) [17] (Table 3). This evidence concerns the gene SLC5A2 and diabetes mellitus.