High levels of expression of ACE2 receptor and transmembrane protease serine 2 have been found in thyroid cells [8, 9], abnormal immune responses and cytokine storm associated to COVID-19 may induce thyroid gland inflammation [9, 19], and both direct and indirect mechanisms might affect hypothalamic-pituitary-thyroid axis [20–24]. This evidence concerns the gene TMPRSS2 and COVID-19.