In addition, our study documents that, among a set of known risk factors, insulin treatment (as a proxy of more severe GDM), pre-pregnancy BMI, and family history of diabetes are the key variables for identifying subgroups of women with a from twofold to fivefold higher risk of developing dysglycemia compared to the reference class (women with BMI lower than 28 kg/m2 not requiring insulin for GDM). The gene discussed is INS; the disease is gestational diabetes.