Deficiency of functional Treg cells caused by mutations of Foxp3 leads to spontaneous systemic multiorgan autoinflammatory phenotypes in mice.39, 40, 41, 42 Interestingly, CD4+CD25+FoxP3+ regulatory T cell-based therapies are proposed for COVID-19 patient management.43 The gene discussed is FOXP3; the disease is COVID-19.