Predictably, oxaloacetate, which is known to increase flux through PEPCK and stiripentol, an antiepileptic drug used in Dravet syndrome patients did not up-regulate either pck1 or pck2 (Fig. 3A and B). This evidence concerns the gene PCK2 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.