PCK2 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Since both scn1lab mutants and patients with Dravet syndrome show hypometabolism, improvement of PEPCK activity or expression could ‘normalize’ metabolic deficits in scn1lab zebrafish to achieve the normal range of glycolysis and consequent substrate flux into mitochondrial energy production.