This study builds on our previous work that demonstrated metabolic deficits and down-regulation of key gluconeogenic genes, pck1 and pck2 in scn1lab mutants, a translatable zebrafish model of Dravet syndrome (Kumar et al., 2016). The gene discussed is PCK1; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.