Several additional transcription factors to MYCN and SOX2 have been associated with NE phenotype, including ASCL1,80 FOXA2,25 E2F1,81 ONECUT2,82 REST,83 and BRN2.84 In particular, FOXA2, ONECUT2, REST, and BRN2 were observed to drive NE phenotype from models displaying classical adenocarcinoma features. This evidence concerns the gene POU3F2 and adenocarcinoma.