Several additional transcription factors to MYCN and SOX2 have been associated with NE phenotype, including ASCL1,80 FOXA2,25 E2F1,81 ONECUT2,82 REST,83 and BRN2.84 In particular, FOXA2, ONECUT2, REST, and BRN2 were observed to drive NE phenotype from models displaying classical adenocarcinoma features. Here, REST is linked to adenocarcinoma.