Out of the 101 genes, we identified 11 MI promoters that were inhibited by obesity, including NPPB, NPPA, IRS1, SMAD3, MIR155, ADRB1, AVP, MAPK14, MC3R, ROCK1, and COL3A1. The gene discussed is NPPA; the disease is obesity due to melanocortin 4 receptor deficiency.