The link between UBB+1 and Alzheimer’s disease (AD) is the most extensively studied and is the subject of several reviews (van Leeuwen et al., 2006; Chadwick et al., 2012; Chen and Petranovic, 2016; Seynnaeve et al., 2018). The gene discussed is UBB; the disease is early-onset autosomal dominant Alzheimer disease.