Intensification of this molecular misreading and an accumulation of UBB+1 in multiple areas of the brain is a hallmark of neurodegeneration, including that associated with Alzheimer’s disease (van Leeuwen et al., 1998; van Leeuwen et al., 2000; van Leeuwen et al., 2002). The gene discussed is UBB; the disease is early-onset autosomal dominant Alzheimer disease.